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Two tubes of The Inkey List Advanced Retinal Serum on a white background
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Close-up of a woman's face with text claiming visible wrinkle reduction in 7 days, clinically proven.
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Advertisement for skin care product showing a woman's face with a yellow patch, text about skin rejuvenation, and participant details.
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Before and after comparison of a skin treatment on a person's forehead.
Before and after comparison of skin treatment on a person's face, showing reduced blemishes.
Before and after comparison of skin treatment showing firmer, more lifted skin.
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Two skincare serum bottles with text describing starter and advanced retinol serums.
Retinal stain on skin with advice on prevention and treatment.
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Advanced 0.05% Retinal Serum Duo

Clinically proven to deliver anti-aging results 11x faster than standard retinol** - with visible improvements in just 1 week*

4.6
Rated 4.6 out of 5 stars
4.6 Stars (97 Reviews)

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What you get: A high-strength Retinal serum, clinically proven to target all 5 visible signs of aging, without irritation - smoothing deep wrinkles, fading dark spots, visibly firming and lifting while boosting skin’s luminosity. Perfect for experienced retinoid users ready to upgrade their anti-aging skincare routine.

Why it works: Formulated with 0.05% encapsulated Retinaldehyde, proven to work 11x faster than standard Retinol***, to accelerate cell turnover, promote collagen production and improve skin elasticity. Enhanced with 2% Sirtalice to visibly lift, tighten and smooth skin in as little as 30 minutes****. Unlike standard retinol serums that require multiple conversion steps, our retinaldehyde formula converts directly to retinoic acid in just one step - delivering faster, more effective anti-aging results.

How it feels: Lightweight, hydrating and fast-absorbing. Skin feels instantly nourished, never drying.

When to use: PM only, 2-3 nights a week to start. Increase frequency as your skin builds tolerance. Always follow with moisturizer and use SPF the next morning.


*** G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

**** Clinical data from ingredient study

Suitable for:

  • Experienced retinoid users
  • All skin types

Targets:

  • Deep Wrinkles
  • Dark Spots
  • Loss of firmness
  • Dullness

Awards & Features

Advanced Retinal Technology: The Next Level Beyond Retinol

Retinoids are the gold-standard for skin longevity - helping improve the look of wrinkles, dark spots and loss of firmness. This Advanced Retinal Serum is for experienced retinol users who want to level up results, without irritation.

  • Why it’s different: Retinal converts to active retinoic acid in one step, so it works 11x faster than standard retinol***. The formula pairs long-term skin renewal with instant firming.

  • What it does: 0.05% encapsulated retinal smooths wrinkles, refines texture and evens tone over time, while 2% Sirtalice™ delivers visible, surface-level firming in as little as 30 minutes**.

  • The results? Skin looks smoother, firmer, and brighter - from 1 week*

Shipping info

Standard tracked shipping

  • $6.99 or FREE on orders over $50. (2-8 business days)

No import duties or fees - Your order will ship domestically from our Canadian warehouse so you can shop with confidence knowing your order will arrive quickly without extra costs

*Find out more about shipping here.

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  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
4.6
Rated 4.6 out of 5 stars
Based on 97 reviews
Total 5 star reviews: 79 Total 4 star reviews: 11 Total 3 star reviews: 2 Total 2 star reviews: 1 Total 1 star reviews: 4
Reviews Summary
Customers say this retinal serum is lightweight, absorbs quickly, and doesn't cause irritation for most users. Many appreciate its gentle formula that works well for sensitive skin without dryness or burning. Users frequently mention visible improvements in skin texture, brightness, and fine lines within weeks of use. The yellow color is commonly noted but doesn't stain when applied properly. Most customers find the price point excellent for the results achieved. Some experienced users prefer it over stronger prescription alternatives. A few customers mention needing more time to see significant results, while others report immediate improvements in skin smoothness and glow.
97 reviews
  • Diane N.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 65+
    Skin Type Combination
    Skin Concerns Fine Lines and Wrinkles, Texture, Plumping
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1-3 weeks
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    Yesterday
    Gentle

    Works well with moisturizer. Does not sting and softens

    my skin.

  • Kathie O.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    Age Range 55 - 64
    Skin Type Normal
    Skin Concerns Fine Lines and Wrinkles
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Friendly? Yes
    Rated 3 out of 5 stars
    2 days ago
    Advance retinol serum

    It makes skin feel soft and not greasy but I have not noticed any difference in facial lines anywhere. I’ve been using for about 4 weeks It just feels like a face cream

  • Stacy E.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 55 - 64
    Skin Type Combination
    Skin Concerns Hyperpigmentation, Fine Lines and Wrinkles, Under Eye Circles
    Have you purchased an INKEY List product before? No
    How long have you used this product for? 1-3 weeks
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    3 days ago
    Great results!

    Great results!