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Two tubes of The Inkey List Advanced Retinal Serum on a white background
Yellow skincare product with text on how to layer a routine
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Close-up of a woman's face with text claiming visible wrinkle reduction in 7 days, clinically proven.
Skincare product with dual-retinoid complex and sirtalice on a white background
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Woman with visible signs of aging, showing product benefits on a white background.
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Before and after comparison of a skin treatment on a person's forehead.
Before and after comparison of skin treatment on a person's face, showing reduced blemishes.
Before and after comparison of skin treatment showing firmer, more lifted skin.
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Two skincare serum bottles with text describing starter and advanced retinol serums.
Retinal stain on skin with advice on prevention and treatment.
Yellow serum bottle with text explaining color variation

Advanced 0.05% Retinal Serum Duo

Clinically proven to deliver anti-aging results 11x faster than standard retinol** - with visible improvements in just 1 week*

4.6
Rated 4.6 out of 5 stars
4.6 Stars (163 Reviews)
$57.00 $60.00 / 15ml Duo

What you get: A high-strength Retinal serum, clinically proven to target all 5 visible signs of aging, without irritation - smoothing deep wrinkles, fading dark spots, visibly firming and lifting while boosting skin’s luminosity. Perfect for experienced retinoid users ready to upgrade their anti-aging skincare routine.

Why it works: Formulated with 0.05% encapsulated Retinaldehyde, proven to work 11x faster than standard Retinol***, to accelerate cell turnover, promote collagen production and improve skin elasticity. Enhanced with 2% Sirtalice to visibly lift, tighten and smooth skin in as little as 30 minutes****. Unlike standard retinol serums that require multiple conversion steps, our retinaldehyde formula converts directly to retinoic acid in just one step - delivering faster, more effective anti-aging results.

How it feels: Lightweight, hydrating and fast-absorbing. Skin feels instantly nourished, never drying.

When to use: PM only, 2-3 nights a week to start. Increase frequency as your skin builds tolerance. Always follow with moisturizer and use SPF the next morning.


*** G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

**** Clinical data from ingredient study

Suitable for:

  • Experienced retinoid users
  • All skin types

Targets:

  • Deep Wrinkles
  • Dark Spots
  • Loss of firmness
  • Dullness

Awards & Features

Advanced Retinal Technology: The Next Level Beyond Retinol

Retinoids are the gold-standard for skin longevity - helping improve the look of wrinkles, dark spots and loss of firmness. This Advanced Retinal Serum is for experienced retinol users who want to level up results, without irritation.

  • Why it’s different: Retinal converts to active retinoic acid in one step, so it works 11x faster than standard retinol***. The formula pairs long-term skin renewal with instant firming.

  • What it does: 0.05% encapsulated retinal smooths wrinkles, refines texture and evens tone over time, while 2% Sirtalice™ delivers visible, surface-level firming in as little as 30 minutes**.

  • The results? Skin looks smoother, firmer, and brighter - from 1 week*

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  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
4.6
Rated 4.6 out of 5 stars
Based on 163 reviews
Reviews Summary
Customers say this retinal serum applies smoothly and feels lightweight on the skin. Many report seeing visible improvements in skin texture, brightness, and fine lines within weeks of use. Users frequently praise its gentle formula, noting minimal to no irritation even for sensitive skin types. The serum absorbs quickly and works well layered with moisturizers. Common observations include a yellow tint to the product and a small tube size. Some users note slower results or no noticeable changes, while others mention concerns about product consistency or packaging efficiency. Overall, most reviewers find it effective and appreciate the affordable price point compared to similar products.
163 reviews
  • Mairead k.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 55 - 64
    Skin Type Combination
    Skin Concerns Fine Lines and Wrinkles, Texture, Oiliness, Hyperpigmentation, Under Eye Circles
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Suitability Suitable for my sensitive skin
    Rated 5 out of 5 stars
    15 hours ago
    Good value for money

    Easy to use retinol cream. Good value for money. Smells nice and goes on lovely

  • Rima
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    5 Stars

    Incredible product

  • Duc H. N.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum Duo
    I recommend this product
    Age Range 25 - 34
    Skin Type Normal
    Skin Concerns Fine Lines and Wrinkles, Texture, Blackheads, Dull Skin
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    1 week ago
    Nice product

    It is a nice product, the only retinal I can find in the market, easy to use, no reaction. But the content is a bit small, making it less cost efficiency. Prefer bigger content for lower price/volume.