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Two tubes of The Inkey List Advanced Retinal Serum on a white background
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Before and after comparison of a skin treatment on a person's forehead.
Before and after comparison of skin treatment on a person's face, showing reduced blemishes.
Before and after comparison of skin treatment showing firmer, more lifted skin.
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Two skincare serum bottles with text describing starter and advanced retinol serums.
Retinal stain on skin with advice on prevention and treatment.
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Advanced 0.05% Retinal Serum Duo

Clinically proven to deliver anti-aging results 11x faster than standard retinol** - with visible improvements in just 1 week*

4.8
Rated 4.8 out of 5 stars
4.8 Stars (65 Reviews)
$41.80 $44.00 / 15ml Duo

Choose your FREE full size mystery gift at cart when you spend $80

What you get: A high-strength Retinal serum, clinically proven to target all 5 visible signs of aging, without irritation - smoothing deep wrinkles, fading dark spots, visibly firming and lifting while boosting skin’s luminosity. Perfect for experienced retinoid users ready to upgrade their anti-aging skincare routine.

Why it works: Formulated with 0.05% encapsulated Retinaldehyde, proven to work 11x faster than standard Retinol***, to accelerate cell turnover, promote collagen production and improve skin elasticity. Enhanced with 2% Sirtalice to visibly lift, tighten and smooth skin in as little as 30 minutes****. Unlike standard retinol serums that require multiple conversion steps, our retinaldehyde formula converts directly to retinoic acid in just one step - delivering faster, more effective anti-aging results.

How it feels: Lightweight, hydrating and fast-absorbing. Skin feels instantly nourished, never drying.

When to use: PM only, 2-3 nights a week to start. Increase frequency as your skin builds tolerance. Always follow with moisturizer and use SPF the next morning.


*** G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

**** Clinical data from ingredient study

Suitable for:

  • Experienced retinoid users
  • All skin types

Targets:

  • Deep Wrinkles
  • Dark Spots
  • Loss of firmness
  • Dullness

Awards & Features

Advanced Retinal Technology: The Next Level Beyond Retinol

Retinoids are the gold-standard for skin longevity - helping improve the look of wrinkles, dark spots and loss of firmness. This Advanced Retinal Serum is for experienced retinol users who want to level up results, without irritation.

  • Why it’s different: Retinal converts to active retinoic acid in one step, so it works 11x faster than standard retinol***. The formula pairs long-term skin renewal with instant firming.

  • What it does: 0.05% encapsulated retinal smooths wrinkles, refines texture and evens tone over time, while 2% Sirtalice™ delivers visible, surface-level firming in as little as 30 minutes**.

  • The results? Skin looks smoother, firmer, and brighter - from 1 week*

Shipping info

Standard tracked shipping

  • $6.99 or FREE on orders over $50. (2-8 business days)

No import duties or fees - Your order will ship domestically from our Canadian warehouse so you can shop with confidence knowing your order will arrive quickly without extra costs

*Find out more about shipping here.

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  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
4.8
Rated 4.8 out of 5 stars
Based on 65 reviews
Total 5 star reviews: 59 Total 4 star reviews: 4 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 1
Reviews Summary
Customers say this retinal serum feels lightweight, absorbs quickly, and layers well without leaving residue or causing irritation. Users report smoother skin texture, reduced fine lines, brighter complexion, and fading dark spots within weeks of use. Many appreciate its gentle formula despite being designed for experienced retinoid users, with minimal burning or dryness. The creamy texture spreads easily and doesn't feel heavy or greasy. Common feedback includes improved skin firmness, more even tone, and a healthy glow. Some mention the yellow tint initially but note it disappears upon application. Reviews consistently praise the affordable price point and effectiveness compared to higher-end alternatives.
65 reviews
  • Chris K.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum Duo
    I recommend this product
    Age Range 45 - 54
    Skin Type Combination
    Skin Concerns Under Eye Circles, Puffiness, Plumping, Fine Lines and Wrinkles, Texture
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1-3 weeks
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    4 days ago
    Refine me!!

    I have used many retinol products before this one is the most affordable, gentle, and something I can use more often than that

  • Carla J.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 35 - 44
    Skin Type Dry
    Skin Concerns Fine Lines and Wrinkles, Dryness
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1-3 weeks
    Sensitive Skin Suitability Suitable for my sensitive skin
    Rated 4 out of 5 stars
    5 days ago
    Good

    Really nice texture. Actually feels moisturising and not at all drying. Used to Retinal already (other brand) and so had no sensitivity and little drying. Doesn’t seem like much in the tube, but it’s nice so I may buy again. Not sure if any improvement since using, but had no break outs so perhaps but whether it’s better than The Ordinary, I don’t yet know .

  • Helen L.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 55 - 64
    Skin Type Sensitive
    Skin Concerns Fine Lines and Wrinkles
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Suitability Suitable for my sensitive skin
    Rated 5 out of 5 stars
    5 days ago
    Impressed !

    Normally use a retinal that’s more expensive. But this ticked boxes and is just as good. Would definitely recommend