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Two tubes of The Inkey List Advanced Retinal Serum on a white background
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Before and after comparison of a skin treatment on a person's forehead.
Before and after comparison of skin treatment on a person's face, showing reduced blemishes.
Before and after comparison of skin treatment showing firmer, more lifted skin.
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Advanced 0.05% Retinal Serum Duo

Clinically proven to deliver anti-aging results 11x faster than standard retinol** - with visible improvements in just 1 week*

4.6
Rated 4.6 out of 5 stars
4.6 Stars (125 Reviews)
$41.80 $44.00 / 15ml Duo

What you get: A high-strength Retinal serum, clinically proven to target all 5 visible signs of aging, without irritation - smoothing deep wrinkles, fading dark spots, visibly firming and lifting while boosting skin’s luminosity. Perfect for experienced retinoid users ready to upgrade their anti-aging skincare routine.

Why it works: Formulated with 0.05% encapsulated Retinaldehyde, proven to work 11x faster than standard Retinol***, to accelerate cell turnover, promote collagen production and improve skin elasticity. Enhanced with 2% Sirtalice to visibly lift, tighten and smooth skin in as little as 30 minutes****. Unlike standard retinol serums that require multiple conversion steps, our retinaldehyde formula converts directly to retinoic acid in just one step - delivering faster, more effective anti-aging results.

How it feels: Lightweight, hydrating and fast-absorbing. Skin feels instantly nourished, never drying.

When to use: PM only, 2-3 nights a week to start. Increase frequency as your skin builds tolerance. Always follow with moisturizer and use SPF the next morning.


*** G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

**** Clinical data from ingredient study

Suitable for:

  • Experienced retinoid users
  • All skin types

Targets:

  • Deep Wrinkles
  • Dark Spots
  • Loss of firmness
  • Dullness

Awards & Features

Advanced Retinal Technology: The Next Level Beyond Retinol

Retinoids are the gold-standard for skin longevity - helping improve the look of wrinkles, dark spots and loss of firmness. This Advanced Retinal Serum is for experienced retinol users who want to level up results, without irritation.

  • Why it’s different: Retinal converts to active retinoic acid in one step, so it works 11x faster than standard retinol***. The formula pairs long-term skin renewal with instant firming.

  • What it does: 0.05% encapsulated retinal smooths wrinkles, refines texture and evens tone over time, while 2% Sirtalice™ delivers visible, surface-level firming in as little as 30 minutes**.

  • The results? Skin looks smoother, firmer, and brighter - from 1 week*

Shipping info

Standard tracked shipping

  • $6.99 or FREE on orders over $50. (2-8 business days)

No import duties or fees - Your order will ship domestically from our Canadian warehouse so you can shop with confidence knowing your order will arrive quickly without extra costs

*Find out more about shipping here.

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  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
4.6
Rated 4.6 out of 5 stars
Based on 125 reviews
Total 5 star reviews: 96 Total 4 star reviews: 17 Total 3 star reviews: 6 Total 2 star reviews: 1 Total 1 star reviews: 5
Reviews Summary
Customers say this retinal serum has a lightweight, smooth texture that absorbs quickly without leaving residue. Many appreciate its gentle formula that doesn't cause irritation, dryness, or flaking like other retinal products. Users report seeing improvements in skin texture, brightness, and smoothness within weeks of use. The yellow-tinted serum layers well under moisturizers and leaves skin feeling soft and hydrated. Common feedback includes reduced appearance of fine lines, dark spots, and more even skin tone. While some mention the small tube size for the price, most find it effective and affordable compared to similar products. A few users didn't notice significant results after several weeks of use.
125 reviews
  • P. A.
    Verified Reviewer
    Reviewing
    Advanced 0.05% Retinal Serum
    I do not recommend this product
    Age Range 55 - 64
    Skin Type Combination
    Skin Concerns Hyperpigmentation, Fine Lines and Wrinkles, Dryness, Dull Skin
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Friendly? Yes
    Rated 1 out of 5 stars
    9 hours ago
    Bring Back The 1% Retinol For Scars, Marks and Wrinkles

    I am seeing a lot of great reviews about the Advanced Retinal Serum, so I was excited to purchase. Unfortunately, I was very disappointed with this newer product. First, the yellow tint is way too much color that it seems to stain on skin when putting it on (unlike the older product) the 1% was a light color that it blended into skin easily. Secondly, I found that this newer product is heavier and stickier NOT lightweight as it states; where the 1% was so nice and light that it glided across skin much easily than this one did. Thirdly, the tube is too small and it seems like not enough product will last long to cover face. The 1% Scar, Mark and Wrinkle Solution was exactly the right tube and product to last a while. Further, I found this newer product to be a little more irritating than the 1% (no problems with that one) and I found that this did not fade any dark spots as quickly as the 1% did and without irritation. Sadly, I am missing the 1% Retinol Serum since it was the best one that The Inkey List offered; where this newer version is a let down. BRING BACK THE 1% RETINOL SERUM FOR SCARS, MARKS and WRINKLES!!!!!!!!!!!!!!!!!!!!!

    IC Profile picture for INKEY CA
    INKEY CA
    4 minutes ago

    Hi, thank you so much for taking the time to share such detailed feedback — we can really see how much you loved the 1% Retinol Serum. That loyalty and passion for our products truly means everything to us.
    We want to be honest with you, the 1% Retinol Scar, Mark and Wrinkle Solution has unfortunately been discontinued and won't be coming back. We completely understand how disappointing that is to hear, especially when it worked so well for you.
    Your feedback on the Advanced Retinal Serum — the colour, texture, tube size and irritation — has been noted and we will absolutely make sure it reaches the right team. Reviews like yours are exactly how we learn and improve, and we don't take that lightly.
    We'd love to help you find the best way to use the Advanced Retinal Serum in the meantime, or explore whether anything else in our range might work for you. Please don't hesitate to reach out to our Customer Experience Team on help@theinkeylist.com — we'd love to help.

  • Marian C.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 65+
    Skin Type Normal
    Skin Concerns Fine Lines and Wrinkles, Puffiness, Under Eye Circles
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1-3 weeks
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    Yesterday
    Lines galore!!!

    Purchased the retinol serum with high hopes. Haven’t seen a ton of improvement. I also feel the tube is small with a lot of space in the tube. I realize I am only supposed to se a peas size amount but it doesn’t feel like there’s much there.

  • Sean H.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 35 - 44
    Skin Type Dry
    Skin Concerns Redness, Fine Lines and Wrinkles, Plumping, Dryness, Texture
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    6 days ago
    Fabulous

    Great product, great price, see improvements already, lovely glow.