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Two tubes of The Inkey List Advanced Retinal Serum on a white background
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Before and after comparison of a skin treatment on a person's forehead.
Before and after comparison of skin treatment on a person's face, showing reduced blemishes.
Before and after comparison of skin treatment showing firmer, more lifted skin.
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Two skincare serum bottles with text describing starter and advanced retinol serums.
Retinal stain on skin with advice on prevention and treatment.
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Advanced 0.05% Retinal Serum Duo

Clinically proven to deliver anti-aging results 11x faster than standard retinol** - with visible improvements in just 1 week*

4.6
Rated 4.6 out of 5 stars
4.6 Stars (123 Reviews)
$41.80 $44.00 / 15ml Duo

What you get: A high-strength Retinal serum, clinically proven to target all 5 visible signs of aging, without irritation - smoothing deep wrinkles, fading dark spots, visibly firming and lifting while boosting skin’s luminosity. Perfect for experienced retinoid users ready to upgrade their anti-aging skincare routine.

Why it works: Formulated with 0.05% encapsulated Retinaldehyde, proven to work 11x faster than standard Retinol***, to accelerate cell turnover, promote collagen production and improve skin elasticity. Enhanced with 2% Sirtalice to visibly lift, tighten and smooth skin in as little as 30 minutes****. Unlike standard retinol serums that require multiple conversion steps, our retinaldehyde formula converts directly to retinoic acid in just one step - delivering faster, more effective anti-aging results.

How it feels: Lightweight, hydrating and fast-absorbing. Skin feels instantly nourished, never drying.

When to use: PM only, 2-3 nights a week to start. Increase frequency as your skin builds tolerance. Always follow with moisturizer and use SPF the next morning.


*** G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

**** Clinical data from ingredient study

Suitable for:

  • Experienced retinoid users
  • All skin types

Targets:

  • Deep Wrinkles
  • Dark Spots
  • Loss of firmness
  • Dullness

Awards & Features

Advanced Retinal Technology: The Next Level Beyond Retinol

Retinoids are the gold-standard for skin longevity - helping improve the look of wrinkles, dark spots and loss of firmness. This Advanced Retinal Serum is for experienced retinol users who want to level up results, without irritation.

  • Why it’s different: Retinal converts to active retinoic acid in one step, so it works 11x faster than standard retinol***. The formula pairs long-term skin renewal with instant firming.

  • What it does: 0.05% encapsulated retinal smooths wrinkles, refines texture and evens tone over time, while 2% Sirtalice™ delivers visible, surface-level firming in as little as 30 minutes**.

  • The results? Skin looks smoother, firmer, and brighter - from 1 week*

Shipping info

Standard tracked shipping

  • $6.99 or FREE on orders over $50. (2-8 business days)

No import duties or fees - Your order will ship domestically from our Canadian warehouse so you can shop with confidence knowing your order will arrive quickly without extra costs

*Find out more about shipping here.

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  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
  • Before and after showing results of Advanced 0.05% Retinal Serum Duo
4.6
Rated 4.6 out of 5 stars
Based on 123 reviews
Total 5 star reviews: 95 Total 4 star reviews: 17 Total 3 star reviews: 6 Total 2 star reviews: 1 Total 1 star reviews: 4
Reviews Summary
Customers say this retinal serum has a lightweight, smooth texture that absorbs quickly without leaving residue. Many appreciate its gentle formula that doesn't cause irritation, dryness, or flaking like other retinal products. Users report seeing improvements in skin texture, brightness, and smoothness within weeks of use. The yellow-tinted serum layers well under moisturizers and leaves skin feeling soft and hydrated. Common feedback includes reduced appearance of fine lines, dark spots, and more even skin tone. While some mention the small tube size for the price, most find it effective and affordable compared to similar products. A few users didn't notice significant results after several weeks of use.
123 reviews
  • Sean H.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 35 - 44
    Skin Type Dry
    Skin Concerns Redness, Fine Lines and Wrinkles, Plumping, Dryness, Texture
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    2 days ago
    Fabulous

    Great product, great price, see improvements already, lovely glow.

  • Susan P.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 65+
    Skin Type Combination
    Skin Concerns Redness, Fine Lines and Wrinkles, Puffiness, Texture, Blackheads
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1-3 weeks
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    2 days ago
    Advanced retinal

    Impressive- improved texture, discoloration and even the appearance of mild rosacea

  • Mark G.
    Verified Buyer
    Reviewing
    Advanced 0.05% Retinal Serum
    I recommend this product
    Age Range 35 - 44
    Skin Type Combination
    Skin Concerns Plumping, Redness, Acne Scars
    Have you purchased an INKEY List product before? Yes
    How long have you used this product for? 1 month - 3 months
    Sensitive Skin Friendly? Yes
    Rated 5 out of 5 stars
    5 days ago
    Using twice a week

    been using this since was out. i'm on my 2nd bottle now. targeting hyperpigmentation and blemishes